Phenotypes Associated with This Genotype

Genotype
MGI:3795453

• Allelic Composition: Cdc73^{Gt(RRE190)Byg}/Cdc73^{Gt(RRE190)Byg}
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:135255 )

• mice die by hatching or implantation

embryo

absent inner cell mass proliferation ( J:135255 )

• cells of the inner cell mass fail to proliferate in culture

absent trophectoderm cell proliferation ( J:135255 )

• cells of the trophectoderm fail to proliferate in culture

reproductive system

failure of embryo implantation ( J:135255 )

♀ • in culture, E3 embryos fail to attach to the bottom of the plate unlike wild-type mice

cellular

absent inner cell mass proliferation ( J:135255 )

• cells of the inner cell mass fail to proliferate in culture

absent trophectoderm cell proliferation ( J:135255 )

• cells of the trophectoderm fail to proliferate in culture