Phenotypes for Sfrp1 Sfrp2 Sfrp5 Vangl2 MGI:3795553 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Sfrp1^tm1Aksh/Sfrp1^tm1Aksh Sfrp2^tm1Aksh/Sfrp2^tm1Aksh Sfrp5^tm1Aksh/Sfrp5⁺ Vangl2^Lp/Vangl2⁺
Genetic Background	involves: 129 * A * C57BL/6 * LPT/LeJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sfrp1^tm1Aksh mutation (1 available); any Sfrp1 mutation (19 available)
Sfrp2^tm1Aksh mutation (1 available); any Sfrp2 mutation (30 available)
Sfrp5^tm1Aksh mutation (0 available); any Sfrp5 mutation (27 available)
Vangl2^Lp mutation (2 available); any Vangl2 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal rostral-caudal body axis extension ( J:135313 )

• mice exhibit an anterior-posterior elongation defect that is enhanced in the trunk relative to that observed in Sfrp1^tm1Aksh/Sfrp1^tm1Aksh Sfrp2^tm1Aksh/Sfrp2^tm1Aksh Sfrp5^tm1Aksh/Sfrp5⁺ mice

• at late head-fold stage, mice exhibit abnormal convergence and extension

open neural tube ( J:135313 )

craniorachischisis ( J:135313 )

abnormal somite development ( J:135313 )

nervous system

open neural tube ( J:135313 )

craniorachischisis ( J:135313 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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