Phenotypes for Sfrp1 Sfrp2 Sfrp5 MGI:3795557 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Sfrp1^tm1Aksh/Sfrp1^tm1Aksh Sfrp2^tm1Aksh/Sfrp2^tm1Aksh Sfrp5^tm1Aksh/Sfrp5^tm1Aksh
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sfrp1^tm1Aksh mutation (1 available); any Sfrp1 mutation (17 available)
Sfrp2^tm1Aksh mutation (1 available); any Sfrp2 mutation (30 available)
Sfrp5^tm1Aksh mutation (0 available); any Sfrp5 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:135313 )

• mice die by E12.5

embryo

abnormal rostral-caudal axis patterning ( J:135313 )

• mice exhibit more severe anterior-posterior axis defects than in Sfrp1^tm1Aksh Sfrp2^tm1Aksh homozygotes

embryonic growth retardation ( J:135313 )

open neural tube ( J:135313 )

• at E9.5

decreased somite size ( J:135313 )

• at E8.5, fused small somites are present

fused somites ( J:135313 )

• at E8.5, fused small somites are present

incomplete somite formation ( J:135313 )

nervous system

open neural tube ( J:135313 )

• at E9.5

growth/size/body

embryonic growth retardation ( J:135313 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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