Phenotypes for Celsr3 Foxg1 MGI:3795739 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Celsr3^tm1Agof/Celsr3^tm2Agof Foxg1^tm1(cre)Skm/Foxg1⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Celsr3^tm1Agof mutation (0 available); any Celsr3 mutation (122 available)
Celsr3^tm2Agof mutation (0 available); any Celsr3 mutation (122 available)
Foxg1^tm1(cre)Skm mutation (2 available); any Foxg1 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

absent anterior commissure ( J:134879 )

abnormal brain internal capsule morphology ( J:134879 )

• despite normal expression in the dorsal thalamus, the three components of the internal capsule (corticothalamic axons, thalamocortical axons and subcerebral projections) are abnormal

• unlike in control mice, no thalamic fibers turn towards the striatum

• however, corticothalamic axons grow towards the ventral telencephalon

abnormal corticospinal tract morphology ( J:134879 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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