Phenotypes for Celsr3 Emx1 MGI:3795740 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Celsr3^tm1Agof/Celsr3^tm2Agof Emx1^tm1(cre)Krj/Emx1⁺
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Celsr3^tm1Agof mutation (0 available); any Celsr3 mutation (122 available)
Celsr3^tm2Agof mutation (0 available); any Celsr3 mutation (122 available)
Emx1^tm1(cre)Krj mutation (2 available); any Emx1 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal anterior commissure morphology ( J:134879 )

• only diminutive bundles originating from the olfactory nuclei run caudally and turn but never cross the midline unlike in control mice (double heterozygotes)

abnormal brain internal capsule morphology ( J:134879 )

• subdural projections develop abnormally

• however, corticothalamic and thalamicortical axons are normal

abnormal corticospinal tract morphology ( J:134879 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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