Phenotypes for Celsr3 Tg(mI56i-cre,EGFP)1Kc MGI:3795743 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Celsr3^tm1Agof/Celsr3^tm2Agof Tg(mI56i-cre,EGFP)1Kc/0
Genetic Background	involves: 129P2/OlaHsd * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Celsr3^tm1Agof mutation (0 available); any Celsr3 mutation (122 available)
Celsr3^tm2Agof mutation (0 available); any Celsr3 mutation (122 available)
Tg(mI56i-cre,EGFP)1Kc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal brain internal capsule morphology ( J:134879 )

• the thalamocortical axons aberrantly run through the pallidum and amygdala

• while corticofugal fibers cross the pallial-subpallial boundary and enter the lateral part of the basal forebrain, they fail to progress and spiral in a disordered manner

• both corticothalamic and thalamocortial axons are abnormal

abnormal corticospinal tract morphology ( J:134879 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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