Phenotypes Associated with This Genotype

Genotype
MGI:3799103

• Allelic Composition: Gnai2^tm1Lbi/Gnai2⁺; Tg(WTbeta2)4Wjk/0
• Genetic Background: B6.Cg-Gnai2^tm1Lbi Tg(WTbeta2)4Wjk

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:125581 )

• mean survival time is 223 days compared to over 600 for control mice and most mice die by 1 year of age

behavior/neurological

fatigue ( J:125581 )

• fatigue occurs in mice with age

cardiovascular system

increased heart weight ( J:125581 )

• the heart to body weight ratio is about twice that of control mice at 7 months of age

dilated heart ( J:125581 )

• heart appears dilated at necropsy

homeostasis/metabolism

cyanosis ( J:125581 )

• occurs in mucosal membranes with age

pulmonary edema ( J:125581 )

• often found at necropsy

ascites ( J:125581 )

• often found at necropsy

liver/biliary system

abnormal liver morphology ( J:125581 )

• liver congestion is often found at necropsy

respiratory system

pulmonary edema ( J:125581 )

• often found at necropsy

respiratory distress ( J:125581 )

• occurs in mice with age

growth/size/body

increased heart weight ( J:125581 )

• the heart to body weight ratio is about twice that of control mice at 7 months of age