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Phenotypes Associated with This Genotype
Genotype
MGI:3799119
Allelic
Composition		 Nfkb1tm1Bal/Nfkb1tm1Bal
Reltm1Grd/Reltm1Grd
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkb1tm1Bal mutation (3 available); any Nfkb1 mutation (102 available)
Reltm1Grd mutation (2 available); any Rel mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal immune system physiology ( J:113514 )
• despite normal development of dendritic cells, CD40LG and TNFSF11-induced survival and IL-12 production are abolished
decreased interleukin-12 secretion ( J:113514 )
• cells induced with LPS produce less IL-12 than similarly treated wild-type cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory