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Phenotypes Associated with This Genotype
Genotype
MGI:3799122
Allelic
Composition		 Nfkb1tm1Bal/Nfkb1tm1Bal
Relatm1Bal/Relatm1Bal
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkb1tm1Bal mutation (3 available); any Nfkb1 mutation (102 available)
Relatm1Bal mutation (1 available); any Rela mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal dendritic cell differentiation ( J:113514 )
• fetal cells transplanted into a lethally irradiated wild-type mice fail to develop dendritic cells unlike mice reconstituted with wild-type cells
• dendritic cell development cannot be restored by reconstitution with wild-type hematopoeitic precursors
• however, myeloid precursor cells are normal
decreased dendritic cell number ( J:113514 )
• in culture, very few dendritic cells differentiate from bone marrow cells

immune system
abnormal dendritic cell differentiation ( J:113514 )
• fetal cells transplanted into a lethally irradiated wild-type mice fail to develop dendritic cells unlike mice reconstituted with wild-type cells
• dendritic cell development cannot be restored by reconstitution with wild-type hematopoeitic precursors
• however, myeloid precursor cells are normal
decreased dendritic cell number ( J:113514 )
• in culture, very few dendritic cells differentiate from bone marrow cells

cellular
abnormal dendritic cell differentiation ( J:113514 )
• fetal cells transplanted into a lethally irradiated wild-type mice fail to develop dendritic cells unlike mice reconstituted with wild-type cells
• dendritic cell development cannot be restored by reconstitution with wild-type hematopoeitic precursors
• however, myeloid precursor cells are normal

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory