Phenotypes Associated with This Genotype

Genotype
MGI:3799161

• Allelic Composition: Timp3^tm1Hest/Timp3^tm1Hest
• Genetic Background: either: B6.129S1-Timp3^tm1Hest or (involves: 129S1/Sv * CD-1)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal choroid vasculature morphology ( J:136890 )

• larger caliber vessels and prominent balloon-like spots are seen

• Background Sensitivity: vascular abnormalities are less prominent in mice on a C57BL/6 background compared to mice on an outbred CD-1 background

• however, the retinal vasculature appears normal

abnormal vascular branching morphogenesis ( J:136890 )

• aortic explants show increased spontaneous microvessel outgrowth which can be inhibited with the addition of recombinant TIMP3 or a VEGFR2 inhibitor

vision/eye

abnormal choroid vasculature morphology ( J:136890 )

• larger caliber vessels and prominent balloon-like spots are seen

• Background Sensitivity: vascular abnormalities are less prominent in mice on a C57BL/6 background compared to mice on an outbred CD-1 background

• however, the retinal vasculature appears normal