Phenotypes Associated with This Genotype

Genotype
MGI:3799208

• Allelic Composition: Nfkb1^tm1Bal/Nfkb1^tm1Bal; Rela^tm1Bal/Rela⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

diarrhea ( J:67107 )

• severe

abnormal colon morphology ( J:67107 )

• mice exhibit colonic perforations and typhlocolitis

large intestinal inflammation ( J:67107 )

• mice exhibit typhlocolitis

cecum inflammation ( J:67107 )

peritoneal inflammation ( J:67107 )

immune system

large intestinal inflammation ( J:67107 )

• mice exhibit typhlocolitis

cecum inflammation ( J:67107 )

peritoneal inflammation ( J:67107 )

increased susceptibility to bacterial infection ( J:67107 )

• mice are more sensitive to typhlocolitis induced by H. hepaticus than wild-type mice with a more rapid onset of diarrhea, enlargement and thickening of the colon, thickening of the mucosa characterized by extensive ulcerations, elongated irregularly shaped glands and crypt abscesses, lamina propria fibrosis and infiltration granulation tissue, dilated lymphatics, and multifocal necrotizing vasculitis with thrombosis, and expanded submucosa and serosa with infiltration