Analysis Tools
neoplasm
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• following pituitary engrafts and exposure to DMBA, mice exhibit reduced induction rates and tumor burden of mammary tumors compared to similarly treated wild-type mice
• both squamous adenocarcinomas (early developing) and type B mammary adenocarcinomas (late developing) are induced by DMBA treatment of mice with pituitary engrafts unlike in similarly treated wild-type mice, which mainly develop squamous adenocarcinomas
• however, DMBA treated mice that do not receive pituitary engrafts exhibit normal tumorigenesis
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endocrine/exocrine glands
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• by day 2 of lactation following gamma irradiation, few normal lobuloalveolar structures are detected unlike in wild-type mice due to increased apoptosis
• pituitary engrafts increase apoptosis by 10-fold and the disruption of lobuloalveolar structures observed during lactation
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integument
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• by day 2 of lactation following gamma irradiation, few normal lobuloalveolar structures are detected unlike in wild-type mice due to increased apoptosis
• pituitary engrafts increase apoptosis by 10-fold and the disruption of lobuloalveolar structures observed during lactation
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homeostasis/metabolism
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• following pituitary engrafts and exposure to DMBA, mice exhibit reduced induction rates and tumor burden of mammary tumors compared to similarly treated wild-type mice
• both squamous adenocarcinomas (early developing) and type B mammary adenocarcinomas (late developing) are induced by DMBA treatment of mice with pituitary engrafts unlike in similarly treated wild-type mice, which mainly develop squamous adenocarcinomas
• however, DMBA treated mice that do not receive pituitary engrafts exhibit normal tumorigenesis
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