Phenotypes Associated with This Genotype

Genotype
MGI:3799632

• Allelic Composition: Ccr9^tm1.1Mal/Ccr9^tm1.1Mal
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell subpopulation ratio ( J:136944 )

• in the lamina propria of the intestine the proportion of CD8+ T cells is reduced and there is a relative increase in CD4+ T cells and B cells

abnormal gamma-delta T cell number ( J:136944 )

• increase in the relative percentage of gamma-delta T cells in the mesenteric lymph node

decreased gamma-delta intraepithelial T cell number ( J:136944 )

• decrease in the total number of intraepithelial lymphocytes primarily apparently due to a reduction in the number of gamma-delta intraepithelial lymphocytes

• only account for 20-30% of the total intraepeithelial lymphocyte T cell population

abnormal mesenteric lymph node morphology ( J:136944 )

• increase in the relative percentage of gamma-delta T cells

hematopoietic system

abnormal T cell subpopulation ratio ( J:136944 )

• in the lamina propria of the intestine the proportion of CD8+ T cells is reduced and there is a relative increase in CD4+ T cells and B cells

abnormal gamma-delta T cell number ( J:136944 )

• increase in the relative percentage of gamma-delta T cells in the mesenteric lymph node

decreased gamma-delta intraepithelial T cell number ( J:136944 )

• decrease in the total number of intraepithelial lymphocytes primarily apparently due to a reduction in the number of gamma-delta intraepithelial lymphocytes

• only account for 20-30% of the total intraepeithelial lymphocyte T cell population