Phenotypes Associated with This Genotype

Genotype
MGI:3800801

• Allelic Composition: Plec^tm5Gwi/Plec^tm5Gwi
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

abnormal skeletal muscle fiber morphology ( J:137067 )

• mitochondria found in focal aggregates with desmin intermediate filaments

decreased skeletal muscle fiber diameter ( J:137067 )

• high fraction of small diameter fibers in soleus and diaphragm

increased skeletal muscle fiber size ( J:137067 )

• high fraction of hypertrophic fibers in soleus and diaphragm

centrally nucleated skeletal muscle fibers ( J:137067 )

• numerous centrally nucleated fibers in the soleus at 1 year

skeletal muscle fiber necrosis ( J:137067 )

• numerous necrotic fibers in the soleus at 1 year

cellular

abnormal aerobic respiration ( J:137067 )

• reduced respiratory activity of mitochondria in muscle fibers