Phenotypes Associated with This Genotype

Genotype
MGI:3801002

• Allelic Composition: Apoc3^tm1Unc/Apoc3^tm1Unc
• Genetic Background: B6.129-Apoc3^tm1Unc/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased susceptibility to diet-induced obesity ( J:105136 )

• male mice on a high fat diet have significant body weight increases compared to controls after 2 weeks on the diet

• male mice are 22% heavier than controls after 20 weeks on a high fat diet

• female mice have a less extreme but still significant weight gain compared to controls after 20 weeks on a high fat diet

adipose tissue

increased white adipose tissue amount ( J:105136 )

• increased amounts of adipose tissue cause the higher weight gain of mice fed a high fat diet for 20 weeks compared to controls fed the same diet

homeostasis/metabolism

abnormal blood homeostasis ( J:105136 )

increased circulating glucose level ( J:105136 )

• mice fed a high-fat diet for 20 weeks have a mean glucose level of 7.25 mmol/l compared to 5.69 mmol/l in control mice

increased circulating leptin level ( J:105136 )

• mice fed a high-fat diet for 20 weeks have a mean leptin serum level of 15.99 ng/ml compared to 6.41 ng/ml in control mice

increased circulating ketone body level ( J:105136 )

• mice fed a high-fat diet for 20 weeks have a mean ketone bodies level of 1.75 mmol/l compared to 1.29 mmol/l in control mice

decreased circulating triglyceride level ( J:105136 )

• triglyceride levels are reduced by almost by half in mice fed a chow diet

• triglyceride levels fail to increase as they do in control mice when a high fat diet is administered

• mice fed a high fat diet for 20 weeks have a triglyceride level that is about one-third of that in control mice

decreased energy expenditure ( J:105136 )

• mice have increased gains in body weight per gram of food consumed after being on a high fat diet for 2 weeks

• the greatest difference in energy expenditure between these mice and control mice is at 4 weeks after the switch to a high fat diet

• differences in energy expenditure gradually decrease but are still significantly less after 20 weeks to the switch to a high fat diet

increased susceptibility to diet-induced obesity ( J:105136 )

• male mice on a high fat diet have significant body weight increases compared to controls after 2 weeks on the diet

• male mice are 22% heavier than controls after 20 weeks on a high fat diet

• female mice have a less extreme but still significant weight gain compared to controls after 20 weeks on a high fat diet

insulin resistance ( J:105136 )

• mice subjected to hyperinsulinemic conditions after being fed a high fat diet for 20 weeks have twice as much insulin in their sera and 4 times less ability to clear insulin

• the insulin-mediated whole body glucose uptake of these mice under these conditions is reduced by more than half compared to controls

lipidosis ( J:105136 )

• a higher uptake of free fatty acids derived from plasma triglyceride leads to a greater increase in adipose tissue mass when mice are fed a high fat diet

• the triglyceride hydrolase actively of the mouse plasma is 78% greater than in controls

behavior/neurological

increased food intake ( J:105136 )

• mice eat 5- to 15% more than controls during the second half of a 20 week feeding of a high fat diet