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Phenotypes Associated with This Genotype
Genotype
MGI:3801089
Allelic
Composition
1700016L21RikTg(Itgax-HBEGF/EGFP)57Lan/0
Genetic
Background
involves: C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
1700016L21RikTg(Itgax-HBEGF/EGFP)57Lan mutation (6 available); any 1700016L21Rik mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• CD11b+ Langerhans cells and alveolar macrophage are depleted following intratracheally administration of diphtheria toxin
• mesenteric lymph nodes are partially depleted following intratracheally administration of diphtheria toxin
• CD11b+ Langerhans cells and alveolar macrophage are depleted following intratracheally administration of diphtheria toxin
• following administration of diphtheria toxin and CD3 stimulation, IFN-gamma production by CD4 and CD8 T cells from the mesenteric lymph nodes is decreased compared to in similarly treated wild-type mice
• following intratracheally administration of diphtheria toxin, mice exhibit increased severity of influenza infection, increased weight loss and delayed clearance compared to infected wild-type mice
• the number of virus-specific cytotoxic T lymphoctes is reduced in mice treated with diphtheria toxin and infected with influenza compared to similarly treated wild-type mcie

respiratory system
• CD11b+ Langerhans cells and alveolar macrophage are depleted following intratracheally administration of diphtheria toxin

hematopoietic system
• CD11b+ Langerhans cells and alveolar macrophage are depleted following intratracheally administration of diphtheria toxin
• mesenteric lymph nodes are partially depleted following intratracheally administration of diphtheria toxin
• CD11b+ Langerhans cells and alveolar macrophage are depleted following intratracheally administration of diphtheria toxin


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory