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Phenotypes Associated with This Genotype
Genotype
MGI:3802830
Allelic
Composition		 Dgcr8Gt(XH157)Byg/Dgcr8+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dgcr8Gt(XH157)Byg mutation (1 available); any Dgcr8 mutation (67 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal spatial working memory ( J:136969 )
• mice exhibit decreased arm choice accuracy compared to wild-type mice

nervous system
abnormal dendrite morphology ( J:136969 )
• mice exhibit a reduction in the number of dendritic spines and mushroom spine dendritic complexity of CA1 pyramidal neurons compared to in wild-type mice
decreased prepulse inhibition ( J:136969 )
• mice exhibit a deficit in prepulse inhibition compared to in wild-type mice

hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:136969 )
N
• despite abnormal prepulse inhibition, mice exhibit normal hearing

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory