Phenotypes Associated with This Genotype

Genotype
MGI:3803022

• Allelic Composition: Tcf4^tm1.1Hmb/Tcf4^tm1.1Hmb
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:136143 )

• pups do not survive

immune system

immune system phenotype ( J:136143 )

N • thymus cellularity and gamma delta T cells are normal

abnormal T cell differentiation ( J:136143 )

• T cell development is partially blocked at DN3 stage

increased double-negative T cell number ( J:136143 )

• despite normal overall proliferation and apoptosis rates, DN3 cells accumulate more than in wild-type mice

abnormal T cell physiology ( J:136143 )

• thymocytes are more sensitive to anti-CD3 induced apoptosis than wild-type cells

• thymocytes are at a disadvantage to reconstitute T cell compartments compared to wild-type cells

hematopoietic system

abnormal T cell differentiation ( J:136143 )

• T cell development is partially blocked at DN3 stage

increased double-negative T cell number ( J:136143 )

• despite normal overall proliferation and apoptosis rates, DN3 cells accumulate more than in wild-type mice

abnormal T cell physiology ( J:136143 )

• thymocytes are more sensitive to anti-CD3 induced apoptosis than wild-type cells

• thymocytes are at a disadvantage to reconstitute T cell compartments compared to wild-type cells