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Phenotypes Associated with This Genotype
Genotype
MGI:3804204
Allelic
Composition		 Ikzf1tm1.1(Pax5)Mbu/Ikzf1+
Tcf3tm1Mbu/Tcf3tm1Mbu
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (4 available); any Commd10 mutation (25 available)
Ikzf1tm1.1(Pax5)Mbu mutation (0 available); any Ikzf1 mutation (30 available)
Tcf3tm1Mbu mutation (1 available); any Tcf3 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:137719 )
N
• development of pro-B cells is rescued
abnormal immunoglobulin heavy chain V(D)J recombination ( J:137719 )
• proximal VH7183-DJH and distal VHJ558-DJH rearrangements of the IgH are reduced compared to in wild-type mice
• Vk-Jk recombination of the Igk locus is absent

hematopoietic system
abnormal immunoglobulin heavy chain V(D)J recombination ( J:137719 )
• proximal VH7183-DJH and distal VHJ558-DJH rearrangements of the IgH are reduced compared to in wild-type mice
• Vk-Jk recombination of the Igk locus is absent

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory