Phenotypes Associated with This Genotype

Genotype
MGI:3804659

• Allelic Composition: Proz^tm1Gjb/Proz^tm1Gjb
• Genetic Background: involves: 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:136102 )

• mice show increased mortality in a collagen/epinephrine-induced thromboembolism model, with 71% of mice dying of respiratory arrest within 5 minutes of model induction compared to 27% in wild-type mice

homeostasis/metabolism

increased susceptibility to induced thrombosis ( J:136102 )

• ferric chloride-induced carotid artery injury leads to 64% occlusion after 40 minutes, which is significantly higher than the 28% occlusion that occurs in wild-type mice

• there is also increased mortality in a thromboembolism model