Phenotypes Associated with This Genotype

Genotype
MGI:3804917

• Allelic Composition: Gria1^tm2Rsp/Gria1^tm2Rsp; Tg(Pvalb-cre)1Mony/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:136763 )

N • mutants show comparable behavior to wild-type in tests for object recognition memory and spatial change

abnormal spatial working memory ( J:136763 )

• moderate impairment is exhibited in rewarded alternation task compared to wild-type

• spatial reference memory is unimpaired in Y maze paradigm

nervous system

abnormal nervous system electrophysiology ( J:136763 )

• power of gamma oscillations in CA3 region hippocampal slices induced by kainate is reduced compared to wild-type

impaired ability to fire action potentials ( J:136763 )

• stronger stimuli are needed to evoke action potential (AP) firing from fast-spiking cells; average probability of firing is close to 1 in wild-type cells vs 0.7 in mutant cells

abnormal excitatory postsynaptic potential ( J:136763 )

• compound EPSPs in interneurons are significantly smaller in slices from mutants than in slices from wild-type; EPSPs also have longer decay times

reduced AMPA-mediated synaptic currents ( J:136763 )

• no reduction in AMPA current is seen at P14, but AMPA-mediated currents are significantly reduced at P42, comparable with the reduction detected in Gria4 mutants at P42