Analysis Tools
nervous system
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• despite neuron loss, no neurofibrillary tangles or plaques are observed
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• mice exhibit a loss of white matter axons in the cerebellum
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• mice exhibit a loss of granular neurons in the cerebellum
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• mice exhibit spongiform degradation in astrocytes ranging from swelling of astrocytic foot processes to vacuolar changes in the entire cell
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• mice exhibit neuron loss accompanied by disorganization of remaining neurons with degenerative changes in their axon lengths
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• normal axoplasm is replaced with axonal swelling with focal accumulation of organelles and often progresses to collapse of the axon
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• mice exhibit spongiform lesions particularly in the cerebellum where loss of white matter axons, Purkinje cells and granular neurons is observed
• mice exhibit spongiform degradation in astrocytes ranging from swelling of astrocytic foot processes to vacuolar changes in the entire cell
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