Phenotypes Associated with This Genotype

Genotype
MGI:3805037

• Allelic Composition: Tnnt2^tm1Feah/Tnnt2^tm1Feah
• Genetic Background: involves: 129S6/SvEvTac * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:137964 )

• mice are all dead by E11.5 to E12.5

embryonic lethality between somite formation and embryo turning, incomplete penetrance ( J:137964 )

• some mouse loss occurs prior to E9.5

cardiovascular system

abnormal myocardial fiber morphology ( J:137964 )

• organized sarcomere structures are absent

abnormal heart development ( J:137964 )

• despite normal heart looping, ventricular walls are thinner than in wild-type or heterozygous mice

pericardial effusion ( J:137964 )

decreased cardiac muscle contractility ( J:137964 )

• spontaneous or electrically-stimulated contraction is absent

embryo

embryonic growth retardation ( J:137964 )

muscle

abnormal myocardial fiber morphology ( J:137964 )

• organized sarcomere structures are absent

decreased cardiac muscle contractility ( J:137964 )

• spontaneous or electrically-stimulated contraction is absent

growth/size/body

embryonic growth retardation ( J:137964 )

homeostasis/metabolism

pericardial effusion ( J:137964 )