Phenotypes Associated with This Genotype

Genotype
MGI:3805039

• Allelic Composition: Tg(Myh6-Tnnt2*)1Feah/0; Tnnt2^tm1Feah/Tnnt2⁺
• Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

dilated heart ( J:137964 )

• massive

dilated cardiomyopathy ( J:137964 )

• mice exhibit severe dilated cardiomyopathy

• left ventricular end diastolic diameter is increased compared to in heterozygous mice with a wild-type transgene

decreased cardiac muscle contractility ( J:137964 )

increased heart rate ( J:137964 )

• non-sustained tachycardia was induced in 2 of 5 mice compared to only 1 of 10 wild-type mice

abnormal heart electrocardiography waveform feature ( J:137964 )

prolonged HV interval ( J:137964 )

prolonged QRS complex duration ( J:137964 )

prolonged QT interval ( J:137964 )

abnormal myocardial fiber physiology ( J:137964 )

• mice exhibit myofiber calcium desensitization

congestive heart failure ( J:137964 )

• evident by molecular markers

muscle

dilated cardiomyopathy ( J:137964 )

• mice exhibit severe dilated cardiomyopathy

• left ventricular end diastolic diameter is increased compared to in heterozygous mice with a wild-type transgene

decreased cardiac muscle contractility ( J:137964 )