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Phenotypes Associated with This Genotype
Genotype
MGI:3805039
Allelic
Composition
Tg(Myh6-Tnnt2*)1Feah/0
Tnnt2tm1Feah/Tnnt2+
Genetic
Background
involves: 129S/SvEv * 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh6-Tnnt2*)1Feah mutation (0 available)
Tnnt2tm1Feah mutation (0 available); any Tnnt2 mutation (52 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• massive
• mice exhibit severe dilated cardiomyopathy
• left ventricular end diastolic diameter is increased compared to in heterozygous mice with a wild-type transgene
• non-sustained tachycardia was induced in 2 of 5 mice compared to only 1 of 10 wild-type mice
• mice exhibit myofiber calcium desensitization
• evident by molecular markers

muscle
• mice exhibit severe dilated cardiomyopathy
• left ventricular end diastolic diameter is increased compared to in heterozygous mice with a wild-type transgene


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory