Phenotypes Associated with This Genotype

Genotype
MGI:3806318

• Allelic Composition: Stat1^tm1Dlv/Stat1^tm1Dlv
• Genetic Background: involves: 129S/SvEv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:99728 )

N • mice are not susceptible to infection with an adapted human coronavirus 229E (HCoV-229E) that was produced by propagating the virus for 4 passages at 37 degrees Celsius on primary embryonic fibroblasts (HCoV-229E-37), showing no virus growth in lung, liver, spleen or small intestine

abnormal MHC II cell surface expression on macrophages ( J:130622 )

• unstimulated bone marrow derived macrophages have much lower expression of class II on cell surface

increased circulating interferon-gamma level ( J:130622 )

• LPS administration leads to about 10-fold higher levels of IFN-gamma in the sera of mice compared to wild-type mice treated with LPS

decreased level of surface class I molecules ( J:130622 )

• unstimulated bone marrow derived macrophages have lower expression of class I on the cell surface

decreased susceptibility to endotoxin shock ( J:130622 )

• no mice die of LPS at a dose of 37 mg/kg body weight compared to 80% of Stat1^tm1Tdec homozygotes dying at this dose

increased susceptibility to bacterial infection ( J:130622 )

• mice all die when infected with 10⁴ or higher Listeria monocytogenes bacteria while all wild-type mice survive

increased susceptibility to Riboviria infection ( J:130622 )

• primary fibroblasts pre-treated with IFN-gamma and then exposed to vesicular stomatitis virus are all dead 24 hours later regardless of the amount of IFN-gamma used

homeostasis/metabolism

increased circulating interferon-gamma level ( J:130622 )

• LPS administration leads to about 10-fold higher levels of IFN-gamma in the sera of mice compared to wild-type mice treated with LPS

vision/eye

vision/eye phenotype ( J:88422 )

N • lens development is normal

hematopoietic system

abnormal MHC II cell surface expression on macrophages ( J:130622 )

• unstimulated bone marrow derived macrophages have much lower expression of class II on cell surface