Phenotypes Associated with This Genotype

Genotype
MGI:3807222

cx6

• Allelic Composition: Tcra^tm1Mom/Tcra/Tcrd^{tm1.1(Tcra)Rsky}; H2^b/H2^b; Tg(Tcrb)93Vbo/?
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased thymocyte number ( J:131357 )

abnormal T cell differentiation ( J:81564 )

• 18% of lymph node T cells from female mice bearing H2-D^b express the HY-alpha t cell receptor chain

• the majority of T cells in male mice are HYalpha⁺ CD4^-CD8^lo or HYalpha⁺ CD4^-CD8^-

• 5 of 29 HY^- thymocytes from H2-D^b background mice have some receptor editing though the small number of DP and SP thymocytes present suggests this process is inefficient

abnormal negative T cell selection ( J:81564 )

• thymocytes from male mice on a H2-D^b background that express the HY receptor are CD69⁺ and undergoing apoptosis due to negative selection

abnormal double-negative T cell morphology ( J:131357 )

• DN thymocytes of both sexes have premature expression of a T cell receptor (TCR)

• this TCR is specific for the male HY antigen and in many cases there is co-expression of CD25 and CD44

• the percentage of DN cells in the thymus is increased

abnormal double-positive T cell morphology ( J:81564 )

• female mice on a H2-D^b background have almost double the number of DP thymocytes compared to female mice carrying just the Tcrbeta transgene

• the majority of these DP thymocytes do not carry the HY TCR

• male mice on a H2-D^b background have 4% the number of double positive thymocytes

decreased double-positive T cell number ( J:131357 )

immune system

decreased thymocyte number ( J:131357 )

abnormal T cell differentiation ( J:81564 )

• 18% of lymph node T cells from female mice bearing H2-D^b express the HY-alpha t cell receptor chain

• the majority of T cells in male mice are HYalpha⁺ CD4^-CD8^lo or HYalpha⁺ CD4^-CD8^-

• 5 of 29 HY^- thymocytes from H2-D^b background mice have some receptor editing though the small number of DP and SP thymocytes present suggests this process is inefficient

abnormal negative T cell selection ( J:81564 )

• thymocytes from male mice on a H2-D^b background that express the HY receptor are CD69⁺ and undergoing apoptosis due to negative selection

abnormal double-negative T cell morphology ( J:131357 )

• DN thymocytes of both sexes have premature expression of a T cell receptor (TCR)

• this TCR is specific for the male HY antigen and in many cases there is co-expression of CD25 and CD44

• the percentage of DN cells in the thymus is increased

abnormal double-positive T cell morphology ( J:81564 )

• female mice on a H2-D^b background have almost double the number of DP thymocytes compared to female mice carrying just the Tcrbeta transgene

• the majority of these DP thymocytes do not carry the HY TCR

• male mice on a H2-D^b background have 4% the number of double positive thymocytes

decreased double-positive T cell number ( J:131357 )

endocrine/exocrine glands

decreased thymocyte number ( J:131357 )