Phenotypes Associated with This Genotype

Genotype
MGI:3807223

cx7

• Allelic Composition: H2^b/H2^b; Tcra/Tcrd^{tm1.1(Tcra)Rsky}/Tcra/Tcrd^{tm1.1(Tcra)Rsky}; Tg(Tcrb)93Vbo/?
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell differentiation ( J:81564 )

• male mice on a H2-D^b background have no distinct double positive or double negative populations in their thymus

abnormal negative T cell selection ( J:81564 )

• almost all thymocytes in male mice on a H2-D^b background undergo negative selection

• receptor editing is unable to rescue these thymocytes

hematopoietic system

abnormal T cell differentiation ( J:81564 )

• male mice on a H2-D^b background have no distinct double positive or double negative populations in their thymus

abnormal negative T cell selection ( J:81564 )

• almost all thymocytes in male mice on a H2-D^b background undergo negative selection

• receptor editing is unable to rescue these thymocytes