immune system
• thymocyte numbers are reduced by about 3-fold
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• the presence of HY TCR alleviates the beta-selection block in Ptcratm1Vbo homozygotes with higher T cell numbers being found in the thymus and the spleen
• despite the increased numbers of thymocytes, the CD25+ thymocyte sub-population still remains very low
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hematopoietic system
• thymocyte numbers are reduced by about 3-fold
|
• the presence of HY TCR alleviates the beta-selection block in Ptcratm1Vbo homozygotes with higher T cell numbers being found in the thymus and the spleen
• despite the increased numbers of thymocytes, the CD25+ thymocyte sub-population still remains very low
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endocrine/exocrine glands
• thymocyte numbers are reduced by about 3-fold
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