Phenotypes Associated with This Genotype

Genotype
MGI:3807289

cx10

• Allelic Composition: H2^b/H2^b; Ptcra^tm1Vbo/Ptcra^tm1Vbo; Tg(TcraH-Y,TcrbH-Y)71Vbo/?
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell differentiation ( J:131357 )

• the presence of HY TCR alleviates the beta-selection block of developing T cells found in Ptcra^tm1Vbo homozygotes resulting in higher T cell numbers being found in the thymus and the spleen

• the presence of the selecting H2^d allele contributes to the rescue of T cell development by the HY-TCR

• despite the increased numbers of thymocytes, the CD25⁺ thymocyte sub-population still remains very low

hematopoietic system

abnormal T cell differentiation ( J:131357 )

• the presence of HY TCR alleviates the beta-selection block of developing T cells found in Ptcra^tm1Vbo homozygotes resulting in higher T cell numbers being found in the thymus and the spleen

• the presence of the selecting H2^d allele contributes to the rescue of T cell development by the HY-TCR

• despite the increased numbers of thymocytes, the CD25⁺ thymocyte sub-population still remains very low