Phenotypes Associated with This Genotype

Genotype
MGI:3807881

• Allelic Composition: Fkbp1b^tm1.1Okam/Fkbp1b^tm1.1Okam
• Genetic Background: ICR.129-Fkbp1b^tm1.1Okam

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:136192 )

N • insulin sensitivity normal

N • pancreatic insulin content normal

decreased insulin secretion ( J:136192 )

• impaired insulin secretion in response to glucose

impaired glucose tolerance ( J:136192 )

• higher blood glucose at 15, 30, and 60 minutes after administration

• plasma insulin is lower at 15 and 30 minutes after glucose administration

endocrine/exocrine glands

decreased insulin secretion ( J:136192 )

• impaired insulin secretion in response to glucose