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Phenotypes Associated with This Genotype
Genotype
MGI:3809286
Allelic
Composition		 Nphp3tm1Cbe/Nphp3tm1Cbe
Genetic
Background		 B6.129P2-Nphp3tm1Cbe
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nphp3tm1Cbe mutation (0 available); any Nphp3 mutation (76 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:139258 )
• mid-gestational lethality

embryo
abnormal embryo turning ( J:139258 )
• left sided tail flexion seen in embryos at E9.5 - E12.5 suggest possible inversion or randomization of turning
abnormal left-right axis patterning ( J:139258 )
• at E9.5 - E13.5, some embryos display either situs reversal (15 of 29) or inconsistent situs (6 of 29) arrangements

cardiovascular system
abnormal heart morphology ( J:139258 )
• complex cardiac defects are seen in embryos at E9.5 - E13.5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory