Phenotypes Associated with This Genotype

Genotype
MGI:3809493

• Allelic Composition: Cebpa^tm1Gonz/Cebpa^tm1Gonz; Tg(SFTPC-rtTA)5Jaw/0; Tg(tetO-cre)1Jaw/0
• Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:106543 )

• mice die within 2 to 3 hours of birth

respiratory system

abnormal lung vasculature morphology ( J:106543 )

• capillary beds in lungs are immature

• however, vascular smooth muscle development is normal

pulmonary vascular congestion ( J:106543 )

• at birth, mice exhibit pulmonary congestion

abnormal lung saccule morphology ( J:106543 )

• between E16.5 and E18.5, mice exhibit reduced dilation of the saccules, thick mesenchyme and a lack of squamous type I cells unlike in wild-type mice

abnormal type I pneumocyte morphology ( J:106543 )

• type I cell maturation is disrupted

absent type I pneumocytes ( J:106543 )

• mature type I cells are absent

abnormal type II pneumocyte morphology ( J:106543 )

• type II cell maturation is disrupted and cells lack stored pulmonary surfactant

atelectasis ( J:106543 )

• at birth

respiratory distress ( J:106543 )

• at birth

abnormal surfactant secretion ( J:106543 )

• mice produce less surfactant protein than wild-type mice

cardiovascular system

abnormal lung vasculature morphology ( J:106543 )

• capillary beds in lungs are immature

• however, vascular smooth muscle development is normal

pulmonary vascular congestion ( J:106543 )

• at birth, mice exhibit pulmonary congestion