Phenotypes Associated with This Genotype

Genotype
MGI:3809494

• Allelic Composition: Cebpa^tm1Gonz/Cebpa^tm1Gonz; Tg(KRT5-cre)5132Jlj/0
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased skin tumor incidence ( J:123139 )

• mice exhibit increased susceptibility to skin tumors induced by DMBA and TPA treatment compared to similarly treated wild-type mice

• pre-alignant tumors induced by DMBA and TPS exhibit increased growth rate compared to in similarly treated wild-type mice

• DMBA and TPA induced tumors exhibit earlier onset, faster progression to malignancy and increased volume compared to in tumors induced in wild-type mice

increased skin papilloma incidence ( J:123139 )

• tumors induced by DMBA and TPA treatment

increased tumor growth/size ( J:123139 )

• DMBA and TPA induced tumors exhibit earlier onset, faster progression to malignancy and increased volume compared to in tumors induced in wild-type mice

increased squamous cell carcinoma incidence ( J:123139 )

• 2 of 13 mice develop squamous cell carcinomas following treatment with DBMA and TPA unlike in wild-type mice

• DMBA and TPA induced tumors progress to malignant squamous cell carcinoma unlike in wild-type cells

integument

integument phenotype ( J:123139 )

N • epidermal homeostasis is normal

increased skin tumor incidence ( J:123139 )

• mice exhibit increased susceptibility to skin tumors induced by DMBA and TPA treatment compared to similarly treated wild-type mice

• pre-alignant tumors induced by DMBA and TPS exhibit increased growth rate compared to in similarly treated wild-type mice

• DMBA and TPA induced tumors exhibit earlier onset, faster progression to malignancy and increased volume compared to in tumors induced in wild-type mice

increased skin papilloma incidence ( J:123139 )

• tumors induced by DMBA and TPA treatment