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Phenotypes Associated with This Genotype
Genotype
MGI:3809645
Allelic
Composition		 Myd88tm1Defr/Myd88tm1Defr
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (4 available); any Commd10 mutation (25 available)
Myd88tm1Defr mutation (4 available); any Myd88 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal NK cell physiology ( J:139001 )
• NK cells fail to make IFN-gamma in response to injections of TLR9 agonists
• NK cells in vivo have a blunted IFN-gamma response to LPS injections

hematopoietic system
abnormal NK cell physiology ( J:139001 )
• NK cells fail to make IFN-gamma in response to injections of TLR9 agonists
• NK cells in vivo have a blunted IFN-gamma response to LPS injections

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory