Phenotypes Associated with This Genotype

Genotype
MGI:3809804

cx17

• Allelic Composition: Apobec3^Gt(XN450)Byg/Apobec3^Rfv3-s; H2^b/H2^d
• Genetic Background: involves: BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to Retroviridae infection induced morbidity/mortality ( J:138778 )

• less than 40% of mice survive viral infection when infected with 140 spleen focus forming units of Friend virus compared to 90% survival in littermate controls

immune system

abnormal immunoglobulin level ( J:138778 )

• the levels of neutralizing antibody produced to Friend virus 28 days after inoculation is over an order of magnitude lower than in controls

increased susceptibility to Retroviridae infection ( J:138778 )

• 16-week old mice mice infected with Friend virus have an order of magnitude more virus in their blood 8 days later than in littermate controls

• less than 40% of mice survive viral infection when infected with 140 spleen focus forming units of Friend virus compared to 90% survival in littermate controls

increased susceptibility to Retroviridae infection induced morbidity/mortality ( J:138778 )

• less than 40% of mice survive viral infection when infected with 140 spleen focus forming units of Friend virus compared to 90% survival in littermate controls

hematopoietic system

abnormal immunoglobulin level ( J:138778 )

• the levels of neutralizing antibody produced to Friend virus 28 days after inoculation is over an order of magnitude lower than in controls