Phenotypes Associated with This Genotype

Genotype
MGI:3810116

• Allelic Composition: Kmt5b^tm1Jnw/Kmt5b^tm1Jnw; Kmt5c^tm1.1Jnw/Kmt5c^tm1.1Jnw; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: 129/Sv * C57BL/6J * C57BL/10 * CBA/Ca

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:139510 )

N • V(D)J recombination in B and T cells is normal

abnormal lymphopoiesis ( J:139510 )

• in a competitive reconstitution assay, cells fail to repopulate the B and T cell population as well as do wild type cells

abnormal class switch recombination ( J:139510 )

• fewer cells undergo the switch from IgM to IgG1 or IgG3 compared to in wild type mice

• however, there is no increase in Igh chromosomal aberrations

decreased double-positive T cell number ( J:139510 )

• in the thymus

decreased B cell number ( J:139510 )

• the number of mature and re-circulating B cells is decreased compared to in wild-type mice

• however, the numbers of pro- and pre-B cells is normal

hematopoietic system

abnormal lymphopoiesis ( J:139510 )

• in a competitive reconstitution assay, cells fail to repopulate the B and T cell population as well as do wild type cells

abnormal class switch recombination ( J:139510 )

• however, there is no increase in Igh chromosomal aberrations

• fewer cells undergo the switch from IgM to IgG1 or IgG3 compared to in wild type mice

decreased double-positive T cell number ( J:139510 )

• in the thymus

decreased B cell number ( J:139510 )

• the number of mature and re-circulating B cells is decreased compared to in wild-type mice

• however, the numbers of pro- and pre-B cells is normal