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Phenotypes Associated with This Genotype
Genotype
MGI:3813813
Allelic
Composition		 H2-T23tm2Cant/H2-T23tm2Cant
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-T23tm2Cant mutation (0 available); any H2-T23 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal CD4-positive, alpha-beta T cell physiology ( J:123555 )
• CD4+ cells are not protected from natural killer cells
• survival of CD4+ lymphocytes is substantially reduced

hematopoietic system
abnormal CD4-positive, alpha-beta T cell physiology ( J:123555 )
• CD4+ cells are not protected from natural killer cells
• survival of CD4+ lymphocytes is substantially reduced

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory