Phenotypes Associated with This Genotype

Genotype
MGI:3814554

• Allelic Composition: Stau1^tm1Apa/Stau1^tm1Apa
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:140557 )

N • overall brain morphology is normal

decreased CNS synapse formation ( J:140557 )

abnormal dendrite morphology ( J:140557 )

• ribonucleic particle localization within dendrites as well as dendrite outgrowth and spine formation are impaired compared to in wild-type mice

• cultured neurons exhibit a reduced protrusion density of dendrites with the presence of more long, thin filopodia-like structures than in wild-type cells

• however, the number of primary dendrites is normal and functional synapses form

behavior/neurological

behavior/neurological phenotype ( J:140557 )

N • despite reduced activity in an open field test, mice do not exhibit increased anxiety related behaviors and hippocampus-dependent learning is intact

decreased locomotor activity ( J:140557 )

• in an open field test