Phenotypes for Cd74 Tap1 MGI:3814823 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Cd74^tm1Doi/Cd74^tm1Doi Tap1^tm1Arp/Tap1^tm1Arp
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74^tm1Doi mutation (1 available); any Cd74 mutation (36 available)
Tap1^tm1Arp mutation (4 available); any Tap1 mutation (51 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal T cell number ( J:113083 )

• numbers of typical (i.e. CD4⁺- or CD8⁺- T cells) are reduced

• T cells that express the canonical mVa19-Ja33 TCR rearrangement are 10-fold more abundant in the lamina propia of the gut compared to controls

immune system

abnormal T cell number ( J:113083 )

• numbers of typical (i.e. CD4⁺- or CD8⁺- T cells) are reduced

• T cells that express the canonical mVa19-Ja33 TCR rearrangement are 10-fold more abundant in the lamina propia of the gut compared to controls

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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