Analysis Tools
immune system
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• about one-third to one-half of mice between 12-18 months of age have auto-antibodies to cardiolipin, myeloperoxidase, and/or dsDNA
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• about one-third of mice between 12-18 months of age have elevated levels of anti-dsDNA IgG antibodies
• these levels are three standard error of means over levels found in age-matched controls
• anti-dsDNA antibodies are also found in 3-month old mice that have been repeatedly injected with LPS while none are found in controls
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• 1 mouse of 13 has overt nephritis
• 6 of 13 mice have high levels of IgG and/or C3 deposition in the kidney
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renal/urinary system
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• 1 mouse of 13 has overt nephritis
• 6 of 13 mice have high levels of IgG and/or C3 deposition in the kidney
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