Phenotypes for Cxcr2 Dstn MGI:3817227 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Dstn^corn1/Dstn^corn1 Cxcr2^tm1Mwm/Cxcr2^tm1Mwm
Genetic Background	involves: 129S2/SvPas * A/WySn * BALB/c * brachy stock

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcr2^tm1Mwm mutation (3 available); any Cxcr2 mutation (30 available)
Dstn^corn1 mutation (0 available); any Dstn mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal cornea morphology ( J:139239 )

• compared to Dstn^corn1 homozygotes with at least one wild type allele of Il8rb, neutrophil recruitment to the cornea is almost completely inhibited; however, macrophages recruitment is still seen

cornea vascularization ( J:139239 )

• the decrease in neutrophil recruitment did not affect corneal vascularization

cardiovascular system

cornea vascularization ( J:139239 )

• the decrease in neutrophil recruitment did not affect corneal vascularization

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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