Analysis Tools
mortality/aging
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• some homozygous mutants, most often female, die spontaneously
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growth/size/body
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• mice homozygous for this mutation exhibit progressive wasting from 5-6 weeks of age
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hematopoietic system
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• the lungs of mutant mice become infiltrated by neutrophils and eosinophils
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• the lungs of mutant mice become infiltrated by neutrophils and eosinophils
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• a week after immunization, mutant mice have reduced ability to kill injected syngeneic MHC class I deficient cells, a natural killer (NK) cell target
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• a week after immunization, mutant mice have reduced ability to kill injected cells presenting the specific antigen, a target for cytotoxic (CD8+) T lymphocytes
• CTL functional impairment occurs later than and is postulated to be a result, rather than the cause, of the physical wasting
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immune system
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• the lungs of mutant mice become infiltrated by neutrophils and eosinophils
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• the lungs of mutant mice become infiltrated by neutrophils and eosinophils
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• a week after immunization, mutant mice have reduced ability to kill injected syngeneic MHC class I deficient cells, a natural killer (NK) cell target
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• a week after immunization, mutant mice have reduced ability to kill injected cells presenting the specific antigen, a target for cytotoxic (CD8+) T lymphocytes
• CTL functional impairment occurs later than and is postulated to be a result, rather than the cause, of the physical wasting
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endocrine/exocrine glands
