Phenotypes Associated with This Genotype

Genotype
MGI:3817770

• Allelic Composition: Nr3c1^{Gt(ESKN92)Hgs}/Nr3c1⁺
• Genetic Background: B6.Cg-Nr3c1^{Gt(ESKN92)Hgs}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal adrenal gland morphology ( J:141205 )

• especially when fed a low fat diet, mice exhibit signs of stimulation of corticosterone and aldosterone producing cells in the zona fasciculate and glomerulosa, respectively, unlike in wild-type mice

• alterations in adrenal gland morphology between mice fed a low fat diet and mice fed a high fat diet are less pronounced than in wild-type mice

abnormal adrenal gland zona fasciculata morphology ( J:141205 )

• column of endocrine cells in the zona fasciculate are longer than in wild-type cells and individual cells have homogeneous eosinophilic cytoplasm

abnormal adrenal gland zona glomerulosa morphology ( J:141205 )

• the zona glomerulosa appears thicker with more glomeruli and hypertrophied epithelium than in wild-type mice

enlarged adrenal glands ( J:141205 )

• adrenal gland weight is higher than in wild-type mice

• unlike in wild-type mice, no additional increase in adrenal gland weight is observed when mice are fed a high fat diet

• enlarged adrenal glands exhibit hyperplasia rather than cellular hypertrophy

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:141205 )

N • mice exhibit normal glucose metabolism when fed a low fat or high fat diet

abnormal circulating corticosterone level ( J:141205 )

• when fed a high fat diet, mice fail to exhibit an increase in corticosterone levels as do wild-type mice

increased circulating corticosterone level ( J:141205 )

• when fed a low fat diet, plasma corticosterone levels are 2-fold higher than in wild-type mice

increased circulating aldosterone level ( J:141205 )

increased circulating angiotensinogen level ( J:141205 )

• when fed a high fat diet, angiotensin levels are increased 3-fold compared to in wild-type mice

increased liver triglyceride level ( J:141205 )

• in the liver when mice are fed a high fat diet

increased renin activity ( J:141205 )

• mice exhibit a 2-fold increase in renin activity compared to in wild-type mice

adipose tissue

adipose tissue phenotype ( J:141205 )

N • mice exhibit normal adipose distribution when fed a low fat or high fat diet

cardiovascular system

increased systemic arterial systolic blood pressure ( J:141205 )

• when fed a low fat diet, mice exhibit hypertension but fail to exhibit further increases in systolic blood pressure when fed a high fat diet

growth/size/body

growth/size/body region phenotype ( J:141205 )

N • mice exhibit normal weight when fed a low fat or high fat diet

renal/urinary system

renal/urinary system phenotype ( J:141205 )

N • despite activation of the renin-angiotension-aldosterone system, mice exhibit normal kidney morphology and function

liver/biliary system

increased liver triglyceride level ( J:141205 )

• in the liver when mice are fed a high fat diet