Phenotypes Associated with This Genotype

Genotype
MGI:3817778

• Allelic Composition: Nr3c1^tm2.1Gsc/Nr3c1^tm2.1Gsc
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:54931 )

• all mice die shortly after birth

endocrine/exocrine glands

abnormal adrenal chromaffin cell morphology ( J:54931 )

• adrenal chromaffin cells exhibit reduced TH, PNMT and chromogranin B immunoreactivity compared to in wild-type mice

• adrenal chromaffin cells fail to express sympathetic neuronal markers unlike in wild-type mice

• however, the number of chromaffin cells, volume density and granule diameter are normal

homeostasis/metabolism

absent circulating adrenaline ( J:54931 )

decreased circulating noradrenaline level ( J:54931 )

hematopoietic system

decreased erythroid progenitor cell number ( J:58790 )

• E14.5 fetal liver cultures fail to exhibit outgrowths of erythroid progenitor cells as do wild-type livers

nervous system

abnormal adrenal chromaffin cell morphology ( J:54931 )

• adrenal chromaffin cells exhibit reduced TH, PNMT and chromogranin B immunoreactivity compared to in wild-type mice

• adrenal chromaffin cells fail to express sympathetic neuronal markers unlike in wild-type mice

• however, the number of chromaffin cells, volume density and granule diameter are normal