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Phenotypes Associated with This Genotype
Genotype
MGI:3817858
Allelic
Composition
Nr3c1tm3Gsc/Nr3c1tm3Gsc
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr3c1tm3Gsc mutation (1 available); any Nr3c1 mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• E14.5 fetal liver cultures fail to exhibit outgrowths of erythroid progenitor cells as do wild-type livers
• mice treated with phenylhydrazine to induce anemia or exposed to hypoxic conditions fail to exhibit an increase in colony forming unit-erythroid cells unlike in similarly treated wild-type mice
• fetal liver cells transplanted into irradiated wild-type mice fail to respond normally with increased erythroid progenitor cell numbers to hypoxic conditions


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory