Phenotypes Associated with This Genotype

Genotype
MGI:3817865

• Allelic Composition: Nr3c1^tm2.1Gsc/Nr3c1⁺
• Genetic Background: B6.129P2-Nr3c1^tm2.1Gsc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased T cell apoptosis ( J:126427 )

• the dose-response curve of glucocorticoid induced T lymphocyte apoptosis is shifted to higher concentrations compared to in wild-type mice

increased susceptibility to experimental autoimmune encephalomyelitis ( J:137157 )

• when subjected to a MOG induced model of experimental autoimmune encephalitis, mice exhibit increased clinical score, resistance to the beneficial effects of dexamethasone treatment and increased T cell and macrophage infiltration compared to in similarly treated wild-type mice

• mice subjected to MOG induced model of experimental autoimmune encephalitis exhibit decreased blood brain barrier integrity

nervous system

abnormal blood-brain barrier function ( J:137157 )

• mice subjected to MOG induced model of experimental autoimmune encephalitis exhibit decreased blood brain barrier integrity

cardiovascular system

abnormal blood-brain barrier function ( J:137157 )

• mice subjected to MOG induced model of experimental autoimmune encephalitis exhibit decreased blood brain barrier integrity

cellular

decreased T cell apoptosis ( J:126427 )

• the dose-response curve of glucocorticoid induced T lymphocyte apoptosis is shifted to higher concentrations compared to in wild-type mice

hematopoietic system

decreased T cell apoptosis ( J:126427 )

• the dose-response curve of glucocorticoid induced T lymphocyte apoptosis is shifted to higher concentrations compared to in wild-type mice