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Phenotypes Associated with This Genotype
Genotype
MGI:3817872
Allelic
Composition
Nr3c1tm2Gsc/Nr3c1tm2Gsc
Tg(Lck-cre)I57Jxm/0
Genetic
Background
B6.Cg-Nr3c1tm2Gsc Tg(Lck-cre)I57Jxm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr3c1tm2Gsc mutation (1 available); any Nr3c1 mutation (35 available)
Tg(Lck-cre)I57Jxm mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• T cells fail to exhibit an increase in apoptosis following treatment with dexamethasone unlike Nr3c1tm2Gsc control cells
• following exposure to MOG, mice exhibit earlier induction of experimental autoimmune encephalomyelitis than in similarly treated wild-type mice and fail to recover after treatment with dexamethasone as do Nr3c1tm2Gsc control mice

homeostasis/metabolism
• T cells fail to exhibit an increase in apoptosis following treatment with dexamethasone unlike Nr3c1tm2Gsc control cells
• following induction of experimental autoimmune encephalomyelitis and treatment with dexamethasone, regulatory T cell numbers are not as diminished as in Nr3c1tm2Gsc control mice and expression of Foxp3 is unaltered
• unlike in peripheral T cells from Nr3c1tm2Gsc control mice, treatment with dexamethasone does not reduced expression of cell adhesion molecules

cellular
• T cells fail to exhibit an increase in apoptosis following treatment with dexamethasone unlike Nr3c1tm2Gsc control cells

hematopoietic system
• T cells fail to exhibit an increase in apoptosis following treatment with dexamethasone unlike Nr3c1tm2Gsc control cells


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory