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Phenotypes Associated with This Genotype
Genotype
MGI:3818420
Allelic
Composition
Fcer1gtm1Rav/Fcer1gtm1Rav
Tyrobptm1.1Viv/Tyrobptm1.1Viv
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcer1gtm1Rav mutation (8 available); any Fcer1g mutation (26 available)
Tyrobptm1.1Viv mutation (1 available); any Tyrobp mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• at E12, the mesometrial lymphoid aggregate of pregnancy is smaller than in wild-type mice
• at E10, the decidua basalis is reduced compared to in wild-type mice
• at E10 in the deciduas basalis and at E12 in the mesometrial lymphoid aggregate of pregnancy
• at E10 and E12, the decidual spiral arterial vessel to lumen area is increased compared to in wild-type mice
• at E12, thick-walled arteries are prominent in implantation site unlike in wild-type mice
• uterine NK cells fail to modify the spiral arteries of the deciduas as in wild-type mice
• fewer mice of one line become pregnant following mating compared to wild-type mice
• midgestational (E10) fetal loss is greater than in wild-type mice
• however, mice derived from a different line exhibit normal pregnancy rates

embryo
• at E12, the mesometrial lymphoid aggregate of pregnancy is smaller than in wild-type mice
• at E10, the decidua basalis is reduced compared to in wild-type mice
• at E10 in the deciduas basalis and at E12 in the mesometrial lymphoid aggregate of pregnancy
• at E10 and E12, the decidual spiral arterial vessel to lumen area is increased compared to in wild-type mice
• at E10 and E12

immune system
• at E10 in the deciduas basalis and at E12 in the mesometrial lymphoid aggregate of pregnancy
• at E6 through E14 in the mesometrial triangle, mesometrial lymphoid aggregate of pregnancy and deciduas basalis

hematopoietic system
• at E10 in the deciduas basalis and at E12 in the mesometrial lymphoid aggregate of pregnancy

endocrine/exocrine glands
• at E10 in the deciduas basalis and at E12 in the mesometrial lymphoid aggregate of pregnancy


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory