Phenotypes Associated with This Genotype

Genotype
MGI:3818499

• Allelic Composition: Syk^tm1Tyb/Syk^tm1Tyb
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal osteoclast differentiation ( J:89583 )

• osteoclast precursors treated in vitro with Tnsfsl1 and macrophage colony stimulating factor exhibit defective osteoclast differentiation compared to similarly treated wild-type cells

• however, markers of mature osteoclast are present and large doses of macrophage colony stimulating factor or transfection of osteoclast precursors with wild-type Syk with functional SH2 domains can partially restore differentiation

decreased bone resorption ( J:89583 )

• osteoclast fail to resorb mineralized matrix in vivo unlike wild-type cells

• neither treatment of osteoclast precursors with large doses of macrophage colony stimulating factor nor coculture with wild-type osteoblasts can rescue bone resoprtion

• however, transfection of osteoclast precursors with wild-type Syk with functional SH2 domains can partially restore bone resoption

immune system

abnormal osteoclast differentiation ( J:89583 )

• osteoclast precursors treated in vitro with Tnsfsl1 and macrophage colony stimulating factor exhibit defective osteoclast differentiation compared to similarly treated wild-type cells

• however, markers of mature osteoclast are present and large doses of macrophage colony stimulating factor or transfection of osteoclast precursors with wild-type Syk with functional SH2 domains can partially restore differentiation

hematopoietic system

abnormal osteoclast differentiation ( J:89583 )

• osteoclast precursors treated in vitro with Tnsfsl1 and macrophage colony stimulating factor exhibit defective osteoclast differentiation compared to similarly treated wild-type cells

• however, markers of mature osteoclast are present and large doses of macrophage colony stimulating factor or transfection of osteoclast precursors with wild-type Syk with functional SH2 domains can partially restore differentiation

cellular

abnormal osteoclast differentiation ( J:89583 )

• osteoclast precursors treated in vitro with Tnsfsl1 and macrophage colony stimulating factor exhibit defective osteoclast differentiation compared to similarly treated wild-type cells

• however, markers of mature osteoclast are present and large doses of macrophage colony stimulating factor or transfection of osteoclast precursors with wild-type Syk with functional SH2 domains can partially restore differentiation