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Phenotypes Associated with This Genotype
Genotype
MGI:3818879
Allelic
Composition		 Ihhtm1Amc/Ihhtm1Amc
Shhtm1Chg/Shhtm1Chg
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ihhtm1Amc mutation (1 available); any Ihh mutation (22 available)
Shhtm1Chg mutation (2 available); any Shh mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
absent vitelline blood vessels ( J:128367 )
• yolk sacs are essentially avascular
failure of initiation of embryo turning ( J:128367 )
• embryos is in primitive unturned position at E9.5
abnormal visceral yolk sac morphology ( J:128367 )
• yolk sacs are thin and transparent
abnormal visceral yolk sac mesenchyme morphology ( J:128367 )
• at E9.5 yolk sac mesoderm is a thin lining of inner yolk sac surface which adheres to mesodermal layer of amnion in some embryos

cardiovascular system
absent vitelline blood vessels ( J:128367 )
• yolk sacs are essentially avascular

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory